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Title: Patnam Rajagopaliengar Krishnaswamy: Innovator in Protein Engineering
Introduction
Patnam Rajagopaliengar Krishnaswamy is a notable inventor based in Bengaluru, India. He has made significant contributions to the field of protein engineering, particularly in the preparation of insulin and the purification of proteins. With a total of 2 patents to his name, his work has implications for both medical and biotechnological applications.
Latest Patents
One of his latest patents is a method for the preparation of insulin by cleavage of a fusion protein. This invention provides a protein precursor of a double-chain molecule that consists of at least two polypeptide chains linked by two disulfide bonds. The precursor has the general formula B—Z—A, where B and A represent the two insulin polypeptide chains, and Z is a polypeptide that includes at least one site for proteolytic cleavage. This innovation allows for the isolation of mature insulin from the secreted double-chain product, enhancing the efficiency of insulin production.
Another significant patent involves a chromatographic agent for the separation and purification of proteins. This agent utilizes phosvitin or a modified phosvitin immobilized and coupled to a suitable matrix. It can be employed for the removal of metal ions from biological material, showcasing its versatility in protein purification processes.
Career Highlights
Throughout his career, Krishnaswamy has worked with various organizations, including the Vittal Mallya Scientific Research Foundation. His expertise in protein engineering has positioned him as a valuable asset in the scientific community, contributing to advancements in biotechnology and medicine.
Collaborations
He has collaborated with notable individuals such as Christopher Hadfield and Peter A Meacock. These collaborations have further enriched his research and innovation efforts, leading to impactful developments in his field.
Conclusion
Patnam Rajagopaliengar Krishnaswamy is a distinguished inventor whose work in protein engineering has paved the way for advancements in insulin production and protein purification. His contributions continue to influence the fields of biotechnology and medicine, demonstrating the importance of innovation in addressing health challenges.