Company Filing History:
Years Active: 2022-2025
Title: Orsolya Barabas: Innovator in Gene Delivery Technologies
Introduction
Orsolya Barabas is a prominent inventor based in Gaiberg, Germany. She has made significant contributions to the field of gene delivery technologies, particularly through her innovative work with transposase polypeptides. With a total of 3 patents to her name, Barabas is recognized for her advancements in the methods of transfection.
Latest Patents
Barabas's latest patents include a transfection method utilizing a Sleeping Beauty transposase variant with increased solubility. This invention relates to improved transposase polypeptides that enhance gene delivery to target cells when used in protein form. The enzyme was developed based on the Sleeping Beauty (SB) transposase, providing further nucleic acids, vectors, and recombinant cells that encode or contain the improved transposase. The invention is particularly useful for gene delivery in genetically modified cell-based therapeutic approaches aimed at treating various diseases.
Another notable patent involves a modified Sleeping Beauty transposase polypeptide that is highly soluble for transfection into cells as an isolated protein. This disclosure presents improved reagents and methods for inserting a transgene into the genome of a living host cell. The variant SB transposase protein is designed to be more soluble while maintaining its transposase activity, thus promoting the recombinant integration of a transgene into a target cell. The modified transposase is stable in electroporation buffer and is rapidly cleared from the host cell within 48 hours.
Career Highlights
Orsolya Barabas is affiliated with the European Molecular Biology Laboratory, where she continues to advance her research in gene delivery technologies. Her work has garnered attention for its potential applications in therapeutic settings.
Collaborations
Barabas collaborates with esteemed colleagues, including Irma Querques and Cecilia Ines Zuliani, contributing to a dynamic research environment that fosters innovation.
Conclusion
Orsolya Barabas is a trailblazer in the field of gene delivery, with her innovative patents paving the way for advancements in therapeutic applications. Her contributions are vital to the ongoing evolution of genetic engineering and transfection methodologies.