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Title: Oksana Lockridge: Innovator in Biochemistry
Introduction
Oksana Lockridge is a prominent inventor based in Bellevue, NE (US). She has made significant contributions to the field of biochemistry, particularly in the development of novel enzyme variants and methods for their application. With a total of 2 patents, her work has implications for both medical and environmental fields.
Latest Patents
Lockridge's latest patents include innovations related to butyrylcholinesterase variants and methods of use. One of her notable inventions provides four butyrylcholinesterase variants that exhibit increased cocaine hydrolysis activity, along with the corresponding encoding nucleic acids. This invention also encompasses libraries of butyrylcholinesterase variants that have at least one amino acid alteration, enhancing their cocaine hydrolysis activity compared to the standard enzyme. Additionally, she has developed methods for hydrolyzing cocaine-based substrates and treating cocaine-induced conditions. Another significant patent involves site-directed mutagenesis of esterases, which allows for the modification of esterases by substituting histidine for at least one amino acid near the active site. This method is particularly useful for detoxifying organophosphates.
Career Highlights
Throughout her career, Oksana Lockridge has worked with esteemed organizations, including the U.S. Government as represented by the Secretary of the Army and the University of Nebraska. Her research has not only advanced scientific understanding but has also contributed to practical applications in health and safety.
Collaborations
Lockridge has collaborated with notable colleagues such as Clarence A. Broomfield and Charles B. Millard. These partnerships have fostered a collaborative environment that enhances innovation and research outcomes.
Conclusion
Oksana Lockridge's contributions to biochemistry through her patents and collaborations highlight her role as a leading inventor in her field. Her work continues to pave the way for advancements in enzyme technology and its applications.