Company Filing History:
Years Active: 1994-1996
Title: O Elmo Millner: A Legacy of Innovation in Beta-Lactamase Research
Introduction
O Elmo Millner was a notable inventor whose contributions to the field of biochemistry have left a lasting impact. He was based in Durham, NC, and held a total of four patents during his career. His work primarily focused on the development of substrates for beta-lactamase, which are crucial in antibiotic resistance research.
Latest Patents
Millner's latest patents include innovative methods for synthesizing chromogenic and fluorogenic beta-lactamase substrates. These substrates are designed to be substantially colorless or nonfluorescent beta-lactam compounds that incorporate an electronegative leaving group. The leaving group can consist of a carbamate, carbonate, thiocarbamate, or thiocarbonate linkage, along with a fluorescent moiety or a moiety capable of producing a visually detectable colored product. Upon the cleavage of the lactam ring by beta-lactamase, the leaving group is liberated, resulting in the production of fluorescence or a colored product.
Career Highlights
Throughout his career, Millner worked at Becton Dickinson and Company Limited, where he made significant advancements in the detection of beta-lactamase. His innovative approaches have contributed to the understanding and management of antibiotic resistance, a critical issue in modern medicine.
Collaborations
Millner collaborated with several esteemed colleagues, including J Michael Quante and Randal A Hoke. These partnerships fostered a collaborative environment that enhanced the research and development of beta-lactamase substrates.
Conclusion
O Elmo Millner's contributions to the field of biochemistry, particularly in the area of beta-lactamase research, have been invaluable. His innovative patents and collaborative efforts have paved the way for advancements in antibiotic resistance detection and management.