Company Filing History:
2 out of 27 
1 out of 1 
1 out of 41 Years Active: 1996-2001
Title: The Innovations of Inventor Nobukazu Hashimoto
Introduction
Nobukazu Hashimoto, hailing from Sayama, Japan, is a notable inventor recognized for his significant contributions to the field of biotechnology. With a total of four patents to his name, his work primarily focuses on the innovative development and purification of chondroitinase, which has crucial applications in medical therapies.
Latest Patents
Hashimoto's latest patents include a detailed work on chondroitinase, encompassing a process for its preparation and a pharmaceutical composition that leverages its properties. One of his key patents describes a crystallizable, purified chondroitinase ABC with a molecular weight of approximately 100,000 daltons, characterized through SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and gel permeation chromatography. The N-terminal and C-terminal amino acids are identified as alanine and proline, respectively. Another vital aspect of his research pertains to a method for purifying this enzyme, which involves the removal of nucleic acids from surfactant solution extracts produced by chondroitinase ABC-producing microorganisms, utilizing chromatographic techniques. Additionally, he has disclosed novel compositions combining chondroitinase with serum albumin, gelatin, or nonionic surfactants, enhancing therapeutic outcomes.
Career Highlights
Throughout his career, Hashimoto has been associated with esteemed organizations such as Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) and Seikgaka Corporation, where he has further honed his skills in innovative biochemistry and enzyme research. His expertise has played a pivotal role in advancing medical applications that utilize enzymatic processes for treatment.
Collaborations
In his journey as an inventor, Hashimoto has collaborated with notable colleagues such as Hideo Mochizuki and Akio Hamai. Their collective efforts have contributed to the success of innovative projects, focusing primarily on the applications and implications of chondroitinase in pharmaceutical formulations.
Conclusion
Nobukazu Hashimoto stands out as a prominent figure in the realm of biotechnology innovation. His substantial patent portfolio, particularly in chondroitinase development, underscores his commitment to enhancing medical treatments through scientific exploration and invention. As his work continues to influence the field, Hashimoto's contributions will undoubtedly pave the way for future advancements in enzyme-based therapies and pharmaceutical applications.