Company Filing History:
Years Active: 2005
Title: Nina Horelli-Kuitunen: Innovator in Genetic Research
Introduction
Nina Horelli-Kuitunen is a prominent inventor based in Helsinki, Finland. She has made significant contributions to the field of genetic research, particularly in understanding autoimmune diseases. Her work has implications for genetic diagnosis and the molecular pathogenesis of specific conditions.
Latest Patents
Nina Horelli-Kuitunen holds a patent for a nucleic acid molecule encoding a (poly)peptide co-segregating in mutated form with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). This patent is crucial as APECED is the only known systemic autoimmune disease with a monogenic background. The research led to the isolation of a novel polynucleotide located on chromosome 21q22.3, identifying five different mutations in APECED patients from various populations. The polypeptide encoded by this polynucleotide is named APGD1, which consists of 545 amino acid residues and features two Cys(4)-His-Cys(3) double-paired finger motifs similar to PHD finger domains. This discovery facilitates direct genetic diagnosis of APECED and provides tools for understanding the disease's molecular pathogenesis.
Career Highlights
Nina works at the National Public Health Institute, where she continues her research in genetics and autoimmune diseases. Her innovative approach and dedication to her field have positioned her as a leading figure in genetic research.
Collaborations
Nina has collaborated with notable colleagues, including Leena Peltonen and Johanna Aaltonen, who have contributed to her research endeavors.
Conclusion
Nina Horelli-Kuitunen's work in genetic research, particularly her patent related to APECED, highlights her significant contributions to the understanding of autoimmune diseases. Her research not only aids in genetic diagnosis but also enhances the understanding of the molecular mechanisms underlying these conditions.