Location History:
- Gainesville, FL (US) (2009 - 2015)
- High Springs, FL (US) (2020 - 2024)
Company Filing History:
Years Active: 2009-2025
Title: Innovations of Nicole Alana Horenstein
Introduction
Nicole Alana Horenstein is a prominent inventor based in High Springs, Florida. She has made significant contributions to the field of pharmacology, particularly in the development of compounds that modulate nicotinic acetylcholine receptors. With a total of six patents to her name, her work has implications for treating various inflammatory conditions.
Latest Patents
Horenstein's latest patents include the development of N,N diethyl-N'phenylpiperazine alpha 7 and alpha 9 nicotinic acetylcholine receptor agonists and antagonists. These patents provide embodiments of para-substituted 1,1-dialkyl-4-phenylpiperazin-1-ium iodides that are advantageous for modulating inflammation. The synthesized compounds have been characterized through electrophysiology activities for α9, α9α10, and α7 nAChRs. The para position of these compounds contains alkyl or aryl amides, or heterocyclic isosteres for the amide. The alkyl groups were varied at the ammonium piperazine nitrogen to assess how changes in size at this position impact function. The compounds were evaluated using two-electrode voltage-clamp measurements on Xenopus oocytes expressing nAChRs. Generally, the compounds exhibited greater potency for α9-containing receptors compared to α7, with most being either full or
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