Company Filing History:
Years Active: 2000-2001
Title: Nandkumar Bongle: Innovator in Oligonucleotide Synthesis
Introduction
Nandkumar Bongle is a notable inventor based in Shrewsbury, MA (US). He has made significant contributions to the field of oligonucleotide synthesis, holding 2 patents that showcase his innovative methods. His work focuses on improving the purity and efficiency of oligonucleotide production, which is crucial for various applications in biotechnology and medicine.
Latest Patents
Bongle's latest patents revolve around the synthesis of extremely high purity oligonucleotides. His method employs dinucleotides, or "dimer blocks," as the fundamental building blocks for synthesis. This approach results in oligonucleotides with a very low N-1 content, typically less than 1-2% of the full-length oligonucleotide. Additionally, his research indicates that using dinucleotide phosphorothioates leads to oligonucleotides with minimal phosphodiester content. Notably, the amount of dimer required in each coupling step can be reduced to less than about 6, with a preference for around 2 equivalents. This innovative method also eliminates the need for the capping step that has traditionally been considered necessary after each coupling.
Career Highlights
Throughout his career, Nandkumar Bongle has worked with prominent companies in the biotechnology sector, including Hybridon, Inc. and Avecia Biotechnology, Inc. His experience in these organizations has contributed to his expertise in oligonucleotide synthesis and innovation.
Collaborations
Bongle has collaborated with notable professionals in his field, including Jin-Yan Tang and Jose Gonzalez. These collaborations have likely enriched his research and development efforts, leading to advancements in oligonucleotide synthesis.
Conclusion
Nandkumar Bongle's contributions to the field of oligonucleotide synthesis are significant and impactful. His innovative methods and patents reflect his dedication to advancing biotechnology. His work continues to influence the development of high-purity oligonucleotides, which are essential for various scientific applications.