Location History:
- Modi'in, IL (1999)
- M.P. Modi'in, IL (2000)
- Hacabim, IL (2006)
Company Filing History:
Years Active: 1999-2006
Title: Moshe Shani: Innovator in Transgenic Research
Introduction
Moshe Shani is a prominent inventor based in Hacabim, Israel. He has made significant contributions to the field of biotechnology, particularly in the development of transgenic animals for medical research. With a total of 3 patents, his work focuses on innovative solutions for cholinergic deficits and drug efficacy evaluation.
Latest Patents
One of his latest patents is titled "Transgenic non-human mammals producing a cholinesterase in their milk." This invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding these novel forms of human AChE have been identified in various malignant tumor cells. Furthermore, this invention includes a transgenic animal assay system for evaluating the efficacy of drugs against cholinergic proteins, which is crucial prior to or during therapeutic treatment. The system utilizes transgenic animals, preferably developing tadpoles or mice that express human AChE, to assess drug efficacy and toxicity of substances that may block human AChE, such as organophosphorous compounds.
Another significant patent is the "Transgenic animal assay system for anti-cholinesterase substances." This invention provides a model system for testing and treating cholinergic deficits and imbalances in mammals. It addresses cognitive functioning in Alzheimer's patients, certain types of retinal photoreceptor degeneration, and hematopoietic disorders. The transgenic animals and their progeny are transformed with a recombinant expression vector that includes a DNA sequence encoding a heterologous cholinesterase (ChE) enzyme and promoter.
Career Highlights
Moshe Shani has been associated with Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., where he has contributed to groundbreaking research in transgenic technology. His work has implications for both therapeutic applications and understanding cholinergic systems in mammals.
Collaborations
He has collaborated with notable researchers such as Hermona Soreq and Haim Zakut, further enhancing the impact of his inventions in the scientific community.
Conclusion
Moshe Shani's innovative work in transgenic research has paved the way for advancements in medical treatments and drug efficacy evaluation. His contributions continue to influence the field and offer promising solutions for various health challenges.