Min Zhang

Title: Min Zhang - Innovator in Cancer Research

Introduction

Min Zhang is a prominent inventor based in Tampa, Florida, known for his significant contributions to cancer research. He has developed innovative solutions aimed at disrupting protein-protein interactions that play a crucial role in cancer progression. His work has the potential to lead to more effective cancer therapies.

Latest Patents

Min Zhang holds a patent for a groundbreaking invention titled "B-catenin/B-cell Lymphoma 9 protein-protein interaction inhibiting peptidomimetics." This patent discloses a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). These sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, selectively disrupting β-catenin/BCL9 protein-protein interactions (PPIs) with remarkable potency. Notably, these peptides can enter cancer cells, bind with β-catenin, and exhibit excellent cellular activity, proving to be much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies have shown that these helical sulfono-γ-AApeptides maintain their integrity, demonstrating no degradation in the presence of pronase for 24 hours, which enhances their biological potential.

Career Highlights

Min Zhang has worked at esteemed institutions such as the University of South Florida and the H. Lee Moffitt Cancer Center and Research Institute. His research has focused on developing innovative therapeutic strategies to combat cancer, showcasing his dedication to improving patient outcomes through scientific advancements.

Collaborations

Throughout his career, Min Zhang has collaborated with notable colleagues, including Jianfeng Cai and Peng Sang. These collaborations have contributed to the advancement of his research and the development of his patented technologies.

Conclusion

Min Zhang's innovative work in cancer research, particularly his patented peptidomimetics, represents a significant advancement in the field. His contributions have the potential to lead to more effective cancer treatments, showcasing the importance of innovation in medical research.