Company Filing History:
Years Active: 2000
Title: Michelle A Mandrekar: Innovator in Nucleic Acid Detection
Introduction
Michelle A Mandrekar is a prominent inventor based in Fitchburg, WI (US). She has made significant contributions to the field of nucleic acid detection, showcasing her expertise and innovative spirit. Her work has implications for various applications in molecular biology and diagnostics.
Latest Patents
Michelle A Mandrekar holds 1 patent related to nucleic acid detection. This invention discloses methods for detecting specific nucleic acid sequences, interrogating the identity of a specific base within a sequence, and assaying endonuclease and exonuclease activity. DNA or RNA probes are hybridized to target nucleic acid sequences. Probes that are complementary to the target sequence at each base are depolymerized, while probes that differ from the target at the interrogation position are not depolymerized. The nucleic acid detection systems utilize the pyrophosphorolysis reaction catalyzed by various polymerases to produce deoxyribonucleoside triphosphates or ribonucleoside triphosphates. dNTPs are transformed to ATP by the action of NDPK. The ATP produced by these reactions is detected by luciferase or NADH-based detection systems.
Career Highlights
Michelle has established herself as a key figure in her field through her innovative work at Promega Corporation. Her contributions have advanced the understanding and capabilities of nucleic acid detection technologies.
Collaborations
Some of her notable coworkers include John William Shultz and Donna M Leippe. Their collaborative efforts have further enhanced the research and development of nucleic acid detection methods.
Conclusion
Michelle A Mandrekar's work in nucleic acid detection exemplifies her dedication to innovation and scientific advancement. Her contributions continue to impact the field positively.