Company Filing History:
Years Active: 2016-2020
Title: The Innovative Contributions of Inventor Michael Hohn
Introduction
Michael Hohn, a prolific inventor based in Scotch Plains, New Jersey, has made significant contributions to the field of biotechnology. With a total of four patents to his name, his work primarily focuses on the development of novel compositions and methods for the synthesis of selenocysteine-containing polypeptides. His innovative approach is paving the way for advancements in protein engineering and recombinant expression systems.
Latest Patents
Hohn's latest patents detail groundbreaking techniques involving non-naturally occurring transfer RNA (tRNA). He has disclosed methods for using these tRNAs to manufacture selenocysteine-containing polypeptides encoded by messenger RNA (mRNA) without the need for a selenocysteine insertion sequence (SECIS) element. In his patents, he describes embodiments where these polypeptides are produced by co-expressing a non-naturally occurring tRNA within a recombinant expression system, which includes components like SerRS, EF-Tu, SelA, PSTK, and SepSecS, alongside an mRNA that has codons compatible with the tRNA's anticodons. This innovation has the potential to streamline the production of proteins engineered to incorporate one or more selenocysteine residues, opening new avenues in biochemistry and molecular biology.
Career Highlights
Michael Hohn is currently affiliated with Yale University, where his research focuses on enhancing our understanding of protein synthesis and engineering. His academic and laboratory pursuits have not only resulted in multiple patents but have also laid the groundwork for future research in his field.
Collaborations
Throughout his career, Michael has collaborated with esteemed colleagues such as Caroline Aldag and Dieter Soll. These partnerships have fostered a dynamic research environment that encourages innovative thinking and collective problem-solving in the realm of biotechnology.
Conclusion
As an inventor, Michael Hohn exemplifies the spirit of innovation, particularly in the area of recombinant protein expression. His patents and research contributions are invaluable to advancing the understanding and utility of selenocysteine in biotechnological applications. With his ongoing work at Yale University, he is poised to continue influencing the future of protein engineering.