Company Filing History:
Years Active: 2025
Title: Michael Harry Brodsky: Innovator in Gene Editing
Introduction
Michael Harry Brodsky is a notable inventor based in Sudbury, Massachusetts. He has made significant contributions to the field of gene editing, particularly in the context of genetic diseases. His innovative work focuses on allele-specific gene editing, which has the potential to transform therapeutic approaches for various genetic disorders.
Latest Patents
Brodsky holds a patent for "Allele-specific inactivation of mutant HTT via gene editing at coding region single nucleotide polymorphisms." This invention contemplates allele-specific gene editing by targeting a heterozygous single nucleotide polymorphism (SNP) in a protein coding sequence associated with a genetic disease. The data presented in his patent demonstrates that this gene editing approach creates a nonsense mutation, leading to a significant reduction of mutant protein without affecting the expression of the wild type protein. The expression of a single CRISPR-Cas9 nuclease in neurons has shown a high frequency of mutations in the targeted HD allele, including both small insertion/deletion mutations and viral vector insertions. This innovative method provides a feasible approach to inactivate autosomal dominant mutations that cause genetic diseases.
Career Highlights
Brodsky is affiliated with the University of Massachusetts, where he continues to advance research in gene editing technologies. His work has garnered attention for its potential applications in treating genetic disorders, showcasing his commitment to scientific innovation and improvement of human health.
Collaborations
Brodsky has collaborated with notable colleagues such as Neil Aronin and Sarah Rinde Oikemus. These partnerships have contributed to the advancement of research in the field of gene editing and have fostered a collaborative environment for innovation.
Conclusion
Michael Harry Brodsky is a pioneering inventor whose work in gene editing holds promise for addressing genetic diseases. His contributions to the field exemplify the impact of innovative research on improving health outcomes.