Company Filing History:
Years Active: 1993
Title: **Michael E. Engel: Pioneer in Biotechnological Innovation**
Introduction
Michael E. Engel is an esteemed inventor based in La Jolla, California. With a significant contribution to the field of biotechnology, he holds a noteworthy patent that enhances the production of biologically active molecules. His innovative work has far-reaching implications in biopharmaceutical applications.
Latest Patents
Michael E. Engel is credited with a patent for the expression of aprotinin in methylotrophic yeast cells. The patent outlines a method of preparing biologically active aprotinin (APR) molecules, which are naturally occurring, relatively short, single-chain polypeptides. The invention involves growing methylotrophic yeast transformants containing a DNA sequence that encodes APR. This is achieved in operational association with a DNA sequence encoding the S. cerevisiae alpha mating factor pre-pro sequence, allowing for effective expression and secretion of APR molecules into the culture medium. The patent also details novel DNA fragments and recombinant yeast strains vital for this innovative process.
Career Highlights
Michael E. Engel has made notable advancements in biotechnology through his role at the Salk Institute Biotechnology Industrial Associates, Inc. His deep understanding of genetic engineering and yeast biology has propelled him to the forefront of biotechnological research. The patent awarded to him signifies his contribution to improving the production of therapeutic proteins, showcasing his dedication to innovation in the life sciences.
Collaborations
Throughout his career, Michael has collaborated with esteemed colleagues, including Thomas S. Vedvick and Mary S. Urcan. These partnerships have fostered a creative environment for groundbreaking research, enabling collaborative advancements in biotechnology. Their combined expertise contributes significantly to the scientific community and enhances the practical applications of their discoveries.
Conclusion
Michael E. Engel stands as a pivotal figure in the realm of biotechnology, marked by his innovative patent that advances the field of protein expression. His work not only exemplifies the spirit of invention but also serves as a foundation for future breakthroughs in the development of biologically active molecules. As he continues his contributions at the Salk Institute Biotechnology Industrial Associates, Inc., the impact of his inventions will resonate within the scientific community and beyond.