Company Filing History:
Years Active: 1993
Title: Michael Altmann: Innovator in mRNA Research
Introduction
Michael Altmann is a notable inventor based in Bern, Switzerland. He has made significant contributions to the field of molecular biology, particularly in the area of mRNA research. His innovative work has led to the development of a unique protein that plays a crucial role in the isolation of capped mRNA.
Latest Patents
Michael Altmann holds a patent for a bifunctional protein designed for the isolation of capped mRNA. This protein comprises at least a first functional site that binds to the cap structure of mRNA and a second functional site that binds to a solid support matrix. This design allows the first functional site to remain functionally accessible while being immobilized. The patent also includes a method for generating a cDNA library that predominantly contains full-length cDNAs. This method involves incubating a mixture of mRNA:cDNA hybrids with a single-strand RNA-specific nuclease and the bifunctional protein. The resulting mixture is passed through a column with a support matrix that binds to the second functional site of the protein, selectively isolating complete mRNA:cDNA hybrids. The process further includes a method for purifying capped mRNA using the same protein.
Career Highlights
Michael Altmann is affiliated with McGill University, where he continues to advance his research in molecular biology. His work has garnered attention for its potential applications in genetic research and therapeutic development.
Collaborations
Michael has collaborated with esteemed colleagues such as Nahum Sonenberg and Isaac Edery, contributing to the advancement of knowledge in the field of mRNA research.
Conclusion
Michael Altmann's innovative contributions to mRNA research highlight his role as a leading inventor in the field. His patented work on bifunctional proteins showcases the potential for advancements in genetic research and therapeutic applications.