Company Filing History:
Years Active: 1996-1998
Title: The Innovations of Matthew W. Harding
Introduction
Matthew W. Harding is a notable inventor based in Acton, MA (US). He has made significant contributions to the field of biotechnology, holding a total of 4 patents. His work primarily focuses on the development of compounds that address multi-drug resistance in cancer therapy.
Latest Patents
Among his latest patents is the invention titled "Isolation of an M.sub.r 52,000 FK506 binding protein and molecular." This patent describes an FK506 binding protein of mammalian origin, isolated through FK506 affinity chromatography. It also includes a corresponding human cDNA of approximate size 2.2 Kb, which was isolated by screening a human placenta cDNA library. The sequence predicts a consensus amino acid sequence present in five FKBP12 sequences and in the human FKBP13 sequence. Another significant patent is "Carbamates and ureas as modifiers of multi-drug resistance." This invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. The pharmaceutical compositions derived from these compounds are particularly effective for treating multi-drug resistant cells and preventing the development of multi-drug resistance.
Career Highlights
Matthew W. Harding is currently employed at Vertex Pharmaceuticals, Inc., where he continues to innovate and contribute to advancements in medical science. His work has been instrumental in developing therapies that combat multi-drug resistance, a significant challenge in cancer treatment.
Collaborations
Throughout his career, Harding has collaborated with esteemed colleagues, including Robert E. Zelle and David M. Armistead. These collaborations have further enhanced the impact of his inventions and research.
Conclusion
Matthew W. Harding's contributions to biotechnology and his innovative patents reflect his commitment to improving therapeutic options for patients facing multi-drug resistance. His work continues to inspire advancements in the field and offers hope for more effective cancer treatments.