This inventor holds 1 USPTO granted patent. Top assignee: The University of Texas System. Active years: 1993.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1993
Title: Innovations of Mathoor Sivaramakrishnan
Introduction
Mathoor Sivaramakrishnan is a notable inventor based in The Woodlands, TX (US). He has made significant contributions to the field of biotechnology, particularly in the development of cytotoxin compositions. His work focuses on innovative methods that enhance our understanding of cellular processes and therapeutic applications.
Latest Patents
Sivaramakrishnan holds a patent for "Macrophage cytotoxin compositions and methods of preparation." This invention provides a cytotoxin composition that inhibits mitochondrial respiration and causes cytostasis in cells, independent of nitric oxide. The invention comprises a conditioned supernatant derived from a macrophage cell line (EA13.5) that inhibits mitochondrial respiration and causes cytostasis in cells. More particularly, the invention comprises a macrophage cytotoxin obtained from conditioned supernatant collected from cultured EA13.5 cells. This macrophage cytotoxin (1) inhibits mitochondrial respiration, (2) causes cytostasis independent of L-arginine derived nitric oxide, and (3) is a weakly acidic glycoprotein with a pI of about 7.5 to 8.0. The invention also discloses a method for producing an L-arginine-derived nitric oxide-independent macrophage cytotoxin by culturing EA13.5 cells, adding IFN-.gamma. and lipopolysaccharide to trigger secretion of the macrophage cytotoxin into the conditioned supernatant, collecting the conditioned supernatant, and isolating the macrophage cytotoxin from the conditioned supernatant. Furthermore, it describes a method for producing a nitric oxide-independent macrophage cytotoxin that inhibits mitochondrial respiration independent of L-arginine from cultured rodent macrophages. Sivaramakrishnan has 1 patent to his name.
Career Highlights
Sivaramakrishnan is affiliated with the University of Texas System, where he continues to engage in research and development. His work has implications for various therapeutic applications, particularly in understanding how macrophages can be utilized in medical treatments.
Collaborations
Some of his notable coworkers include Stanley D. Tucker and Jim Klostergaard, who have contributed to his research endeavors.
Conclusion
Mathoor Sivaramakrishnan's innovative work in the field of cytotoxin compositions
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile