Masanori Kitamura

Title: Innovations of Masanori Kitamura in Gene Delivery

Introduction

Masanori Kitamura is a notable inventor based in London, GB, recognized for his contributions to the field of gene therapy. He has been instrumental in developing innovative methods for the delivery of gene products, particularly within renal glomeruli. His work has led to significant advancements in the understanding and application of gene therapy techniques.

Latest Patents

Masanori Kitamura holds three patents, with his latest focusing on the delivery of gene products via mesangial cells. This patent discloses methods that achieve site-directed delivery, in situ amplification, and sustained expression of an exogenous gene product within renal glomeruli. In his research, an exogenous gene, E. coli β-galactosidase, was introduced into cultured rat mesangial cells using a replication-defective retrovirus. The stable infectants were then administered to a rat kidney via the renal artery. Remarkably, the engineered mesangial cells populated 40% of glomeruli site-specifically, and the gene product was detected throughout a 14-week observation period. In an alternative method, the engineered mesangial cells were injected into a kidney subjected to an antibody that induces mesangiolysis, followed by mesangial regeneration. Under these conditions, the expression of β-galactosidase was dramatically amplified in situ, with high-level expression continuing for at least 8 weeks.

Career Highlights

Masanori Kitamura is affiliated with The Jikei University School of Medicine, where he has contributed to various research initiatives. His work has garnered attention for its potential applications in treating renal diseases through innovative gene delivery methods.

Conclusion

Masanori Kitamura's innovative approaches to gene delivery represent a significant advancement in the field of gene therapy. His patents and research continue to pave the way for future developments in medical science.