Company Filing History:
Years Active: 2002
Title: The Innovative Contributions of Inventor Mary Lui
Introduction
Mary Lui, a notable inventor based in Kew Gardens, NY, has made significant advancements in the field of molecular biology. With a total of 2 patents to his name, he is recognized for his cutting-edge research involving mammalian proteins and their interactions, particularly in the context of rapamycin.
Latest Patents
One of Mary Lui's latest patents focuses on mammalian proteins that bind to FKBP12 in a rapamycin-dependent manner. This includes a protein complex containing 245 kDa and 35 kDa components known as RAFT1 and RAFT2. The interaction of this complex with FKBP12 has pharmacological characteristics that align with the in vivo effects of rapamycin, occurring at low nanomolar concentrations and competing with excess FK506. The patent further details the sequences of tryptic peptides derived from the affinity-purified RAFT1, revealing strong homologies to predicted products of yeast TOR genes, which are integral in rapamycin resistance in yeast. A cDNA for RAFT1 was obtained, encoding a 289 kDa protein composed of 2550 amino acids, with a notable identity percentage of 43% and 39% to TOR2 and TOR1, respectively.
Career Highlights
Mary Lui is affiliated with The Johns Hopkins University, where he engages in pioneering research that propels the understanding of protein interactions and their implications in pharmacology. His innovative work not only contributes to academic knowledge but also has potential applications in therapeutic strategies.
Collaborations
Throughout his career, Mary has collaborated with esteemed colleagues such as David M. Sabatini and Hediye Erdjument-Bromage. These associations have enriched his research endeavors, combining diverse expertise to further explore the complexities of protein interactions and their therapeutic potentials.
Conclusion
In conclusion, Mary Lui stands out as a remarkable inventor with significant contributions to the field of molecular biology. His patents highlight the importance of understanding mammalian proteins and their interactions, paving the way for future innovations in pharmacology and treatment methodologies. His collaborative spirit and dedication to research continue to inspire advancements in the scientific community.