Company Filing History:
Years Active: 2013-2019
Title: Martin Allan: Innovator in Protein Conjugation and Aldosterone Synthase Inhibition
Introduction
Martin Allan is a distinguished inventor based in Cambridge, MA (US), known for his contributions to the fields of biochemistry and pharmaceuticals. With a total of 2 patents, he has made significant strides in developing innovative methods for creating protein conjugates and therapeutic compounds.
Latest Patents
Among his latest patents, one notable invention is titled "Methods for making conjugates from disulfide-containing proteins." This invention provides methods to prepare protein conjugates from proteins that possess at least four accessible cysteine residues. In one embodiment, an antibody with four reducible disulfide linkages is reduced to yield four pairs of free cysteines. Each pair of free cysteines is then reacted with a 1,3-dihaloacetone or a similar reactant, linking the sulfur atoms of each pair through a three-carbon tether with a reactive ketone. This method results in a stabilized antibody conjugate with high selectivity for a ratio of two payloads per antibody.
Another significant patent is for "Aryl-pyridine derivatives as aldosterone synthase inhibitors." This invention provides a compound of a specific formula or a pharmaceutically acceptable salt thereof, with defined variables. It also relates to a method for manufacturing these compounds and their therapeutic applications. Furthermore, the invention includes a combination of pharmacologically active agents and a pharmaceutical composition.
Career Highlights
Martin Allan is currently employed at Novartis AG, a leading global healthcare company. His work focuses on innovative solutions that address critical health challenges through advanced research and development.
Collaborations
Throughout his career, Martin has collaborated with notable colleagues, including Qi-Ying Hu and Sylvie Chamoin. These partnerships have contributed to the advancement of his research and the successful development of his patented inventions.
Conclusion
Martin Allan's innovative work in protein conjugation and aldosterone synthase inhibition showcases his commitment to advancing pharmaceutical science. His contributions continue to impact the field positively, paving the way for future developments in therapeutic applications.