Markus O Imhof

Title: Innovations of Markus O Imhof

Introduction

Markus O Imhof is a notable inventor based in Ecublens, Switzerland. He has made significant contributions to the field of genetic engineering, particularly in the area of regulated gene expression. With a total of two patents to his name, his work has the potential to advance biotechnological applications.

Latest Patents

Imhof's latest patents focus on a potent genetic switch that allows for regulated gene expression in eukaryotic cells. The invention provides a system for controlled transgene transcription using chimeric activator and repressor proteins functioning within a novel regulatory network. In non-inducing conditions, the target transgene is actively silenced by a new class of chimeric proteins, which consist of the DNA-binding tetracycline repressor fused to distinct multimerized eukaryotic transcriptional repression domains. When a tetracycline "inducer" is present, the repressor does not bind to the promoters for both the target gene and another regulatory gene encoding a transactivator, such as GAL4-VP16. Under these inducing conditions, the transactivator activates the expression of the target transgene and its own gene, creating an additional autoregulatory positive feedback loop.

Career Highlights

Markus O Imhof has established a prominent career at the University of Lausanne, where he continues to innovate in the field of genetic research. His work has garnered attention for its potential applications in various biotechnological fields.

Collaborations

Imhof has collaborated with notable colleagues, including Nicolas Mermod and Philippe Chatellard, who have contributed to his research endeavors.

Conclusion

Markus O Imhof's contributions to genetic engineering through his innovative patents highlight the importance of regulated gene expression in advancing biotechnological applications. His work at the University of Lausanne continues to pave the way for future discoveries in this vital field.