Company Filing History:
Years Active: 1992-1996
Title: **Mark Krystal: Innovator in Recombinant RNA Virus Research**
Introduction
Mark Krystal, based in Leonia, NJ, is an accomplished inventor known for his significant contributions to the field of recombinant negative strand RNA viruses. With a total of two patents, his work focuses on creating innovative solutions for gene expression and viral research, showcasing the pivotal role of inventors in advancing science and technology.
Latest Patents
Mark Krystal's latest patents include groundbreaking methods for recombinant negative strand RNA virus templates. These RNA templates are designed for expressing heterologous gene products and constructing chimeric viruses. His research involved the use of influenza viral polymerase, which was prepared devoid of viral RNA, to replicate small RNA templates from plasmid-encoded sequences. The findings revealed that constructions containing the 3' end of genomic RNA could be efficiently copied, indicating that the promoter was located solely within the 15 nucleotide 3' terminus. Importantly, sequences not specific to the influenza viral termini were excluded from copying, while RNAs with identical termini to plus sense cRNA were transcribed at low levels. Mark also emphasized the need for elevated levels of viral proteins for effective catalysis in both cap-endonuclease primed and primer-free RNA synthesis. His innovative approaches have led to high levels of expression of heterologous genes, marking significant advancements in the field.
Career Highlights
Throughout his career, Mark has made impactful contributions to both academic and corporate environments. He has worked with esteemed institutions such as Mount Sinai School of Medicine, contributing his expertise in virology and gene expression. His innovative methods and solutions have positioned him as a notable figure within research and development sectors.
Collaborations
Mark Krystal has collaborated with prominent colleagues in the field, including Peter M. Palese and Jeffrey D. Parvin. These partnerships have played a crucial role in advancing their research endeavors and have fostered new techniques and methodologies in the study of RNA viruses.
Conclusion
Mark Krystal exemplifies the spirit of innovation and collaboration in the scientific community. His inventions and patents not only enhance our understanding of viral mechanisms but also pave the way for future advancements in genetic research and therapeutic applications. As we continue to explore the realms of virology and gene therapy, the contributions of inventors like Mark serve as a vital foundation for future discoveries.