Company Filing History:
Years Active: 2023-2025
Title: Innovations of Mark Ambroso in Polymerase Technology
Introduction
Mark Ambroso is a notable inventor based in Escondido, California. He has made significant contributions to the field of biotechnology, particularly in the development of engineered polymerases. With a total of six patents to his name, Ambroso's work has advanced the capabilities of polymerase enzymes used in various applications.
Latest Patents
Ambroso's latest patents include innovative engineered variants of archaeal, prokaryotic, and eukaryotic polymerases. These variants exhibit enhanced thermostability, improved incorporation of 3' modified nucleotides, and increased uracil-tolerance in polymerase-catalyzed nucleotide extension reactions compared to wild type polymerase enzymes. Additionally, these engineered polymerases are designed for forming complexed polymerases, binding complexes, and ternary complexes, which are essential for conducting nucleic acid sequencing reactions. Another significant patent focuses on engineered variants of archaeal polymerases that demonstrate exonuclease-minus activity, enhanced thermostability, and reduced sequence-specific errors in nucleotide binding and extension reactions.
Career Highlights
Mark Ambroso is currently employed at Element Biosciences, Inc., where he continues to push the boundaries of polymerase technology. His work has been instrumental in developing tools that enhance the accuracy and efficiency of nucleic acid sequencing, which is crucial for various applications in genomics and molecular biology.
Collaborations
Ambroso collaborates with talented individuals in his field, including Matthew William Kellinger and Tyler Lopez. These partnerships foster innovation and contribute to the advancement of biotechnology.
Conclusion
Mark Ambroso's contributions to engineered polymerases have significantly impacted the field of biotechnology. His innovative patents and collaborations continue to drive advancements in nucleic acid sequencing technologies.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.