Company Filing History:
1 out of 21 
1 out of 1 Years Active: 2021-2024
Title: The Innovations of Mario Bunse
Introduction
Mario Bunse is a notable inventor based in Berlin, Germany. He has made significant contributions to the field of genetic engineering, particularly in the development of transposon-based transfection systems. With a total of 2 patents, his work has implications for medical applications, especially in immunotherapy.
Latest Patents
One of Mario Bunse's latest patents is a transposon-based transfection system for primary cells. This invention relates to a transfection kit suitable for primary cells, such as T cells. It comprises mRNA encoding a transposase, or reagents for generating mRNA encoding said transposase, as well as minicircle DNA comprising the transposon. The invention also includes a nucleic acid, preferably a DNA minicircle, that comprises a transposon encoding a protein and at least one miRNA. The sequences encoding the miRNA are located in an intron, and the expression of the protein and the miRNA is regulated by the same promoter. Additionally, the invention provides a population of cells obtainable with the method, along with methods of transfection and medical uses, particularly in adoptive T cell therapy or T cell receptor (TCR) or chimeric antigen receptor (CAR) gene therapy.
Career Highlights
Mario Bunse has worked at the Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft. His experience in this prestigious research institution has allowed him to further his research and innovations in genetic engineering.
Collaborations
Throughout his career, Mario has collaborated with notable colleagues such as Wolfgang Uckert and Julian Clauss. These collaborations have contributed to the advancement of his research and the successful development of his inventions.
Conclusion
Mario Bunse is a distinguished inventor whose work in genetic engineering has led to innovative solutions in the field. His contributions, particularly in transposon-based transfection systems, have the potential to impact medical therapies significantly.