Company Filing History:
Years Active: 2005
Title: Marie-Laure Yaspo: Innovator in Autoimmune Research
Introduction
Marie-Laure Yaspo is a prominent inventor based in Berlin, Germany. She has made significant contributions to the field of autoimmune diseases, particularly through her research on Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). Her work has implications for genetic diagnosis and understanding the molecular pathogenesis of this rare condition.
Latest Patents
Marie-Laure Yaspo holds a patent for a nucleic acid molecule encoding a (poly)peptide that co-segregates in mutated form with APECED. This patent is crucial as APECED is the only known systemic autoimmune disease with a monogenic background. The research led to the isolation of a novel polynucleotide located on chromosome 21q22.3, where five different mutations in APECED patients from various populations were identified. The polypeptide encoded by this polynucleotide is named APGD1, which consists of 545 amino acid residues and features two Cys(4)-His-Cys(3) double-paired finger motifs similar to PHD finger domains. This discovery facilitates direct genetic diagnosis of APECED and provides essential tools for dissecting the disease's molecular pathogenesis.
Career Highlights
Marie-Laure Yaspo is affiliated with the National Public Health Institute, where she continues her research and innovation in the field of autoimmune diseases. Her work has garnered attention for its potential to improve diagnostic methods and therapeutic strategies for APECED.
Collaborations
Marie-Laure has collaborated with notable researchers, including Leena Peltonen and Johanna Aaltonen, who have contributed to her work in understanding the genetic aspects of autoimmune diseases.
Conclusion
Marie-Laure Yaspo's innovative research and patent in the field of autoimmune diseases highlight her significant contributions to medical science. Her work not only advances our understanding of APECED but also paves the way for improved diagnostic and therapeutic approaches.