Marie-Claude C Senut

Title: Marie-Claude C Senut: Innovator in Hormone Receptor Research

Introduction

Marie-Claude C Senut is a distinguished inventor based in La Jolla, California. She has made significant contributions to the field of biological studies, particularly in the area of hormone receptor functionality. Her innovative work has led to the development of novel chimeric proteins that have potential applications in gene modulation.

Latest Patents

Marie-Claude C Senut holds a patent for "Hormone receptor functional dimers and methods of their use." This invention provides chimeric proteins that consist of at least two functional protein units, each containing a dimerization domain from the steroid/thyroid hormone nuclear receptor superfamily. These chimeric proteins can crystallize to form functional entities, which may include a flexible peptide linker designed to enhance the preparation of variant chimeric proteins. The functional entities exhibit unique DNA binding characteristics that differ from wild-type complexes, with some functioning as transactivators and others as constitutive repressors. The patent also includes nucleotide sequences encoding these proteins, methods for their use, and isolated protein crystals suitable for x-ray diffraction analysis.

Career Highlights

Marie-Claude C Senut is affiliated with the Salk Institute for Biological Studies, where she conducts her research. Her work has garnered attention for its innovative approach to understanding hormone receptor dynamics and their implications in gene expression.

Collaborations

Marie-Claude has collaborated with notable scientists such as Fred Harrison Gage and Steven T Suhr, contributing to a rich environment of research and innovation.

Conclusion

Marie-Claude C Senut's contributions to the field of hormone receptor research exemplify the impact of innovative thinking in biological sciences. Her patented work on chimeric proteins opens new avenues for gene modulation and therapeutic applications.