Company Filing History:
Years Active: 2016-2017
Title: Innovations by Marianna Zaretzky
Introduction
Marianna Zaretzky is a prominent inventor based in Beer Sheva, Israel. She has made significant contributions to the field of biotechnology, particularly in the development of proteins that play a crucial role in inflammatory responses.
Latest Patents
Zaretzky holds two notable patents. The first patent is for IL-17R-ECD mutants and methods of using the same. This invention involves a protein comprising an amino acid sequence with at least 97% homology to SEQ ID NO: 1. The amino acid sequence includes valine at position 60, glycine at position 123, and lysine at position 109, and the protein binds to hIL17A. The second patent also pertains to IL-17R-ECD mutants and methods of using the same. It provides engineered soluble hIL-17RA receptors with high affinity to hIL-17, which inhibit downstream IL17A induced signaling events in cells. Additionally, it includes methods for inhibiting hIL-17A induced secretion of CXCL1 and/or IL-6 in cells, as well as methods for treating inflammation and/or inflammatory disorders in a subject.
Career Highlights
Zaretzky is affiliated with the National Institute for Biotechnology in the Negev Ltd., where she conducts her research and development work. Her innovative approaches have positioned her as a key figure in her field.
Collaborations
Zaretzky collaborates with Amir Aharoni, contributing to advancements in biotechnology and the development of therapeutic solutions.
Conclusion
Marianna Zaretzky's work in biotechnology, particularly her patents related to IL-17R-ECD mutants, showcases her innovative spirit and dedication to addressing inflammatory disorders. Her contributions are significant in the ongoing quest for effective treatments in this area.