Company Filing History:
Years Active: 2023
Title: The Innovative Contributions of Marianna Trakala
Introduction
Marianna Trakala is a notable inventor based in Cambridge, MA (US). She has made significant strides in the field of regenerative medicine through her innovative research and inventions. Her work focuses on enhancing the potential of pluripotent cells, which are crucial for various medical applications.
Latest Patents
Marianna Trakala holds a patent for a method titled "Method for expanding stemness and differentiation potential of pluripotent cells." This invention is based on the discovery that increasing micro RNA-203 levels in induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) enhances their quality and ability to differentiate into multiple cell lineages. The method allows these cells to achieve further maturation properties without compromising their self-renewal capabilities. The effect is mediated through the miR-203-dependent control of de novo DNA methyltransferases Dnmt3a and Dnmt3b, which regulate the methylation landscape of pluripotent cells. This innovative approach can be implemented by overexpressing micro RNA-203 or by adding it or its analogues to the cell culture medium. The generated cells exhibit improved capacity for differentiation, making them valuable for regenerative medicine strategies.
Career Highlights
Throughout her career, Marianna has worked with esteemed organizations, including the National Center for Cancer Research (CNIO) in Spain. Her research has contributed to the understanding of stem cell biology and its applications in medicine.
Collaborations
Marianna has collaborated with notable colleagues such as Marcos Malumbres and Maria Salazar-Roa, who have also made significant contributions to the field of cancer research and stem cell biology.
Conclusion
Marianna Trakala's innovative work in expanding the potential of pluripotent cells has significant implications for regenerative medicine. Her contributions continue to pave the way for advancements in medical science and therapy.