Marian R Wachtel

Title: Innovations of Marian R Wachtel in Immunology

Introduction

Marian R Wachtel is a notable inventor based in Gaithersburg, MD (US). He has made significant contributions to the field of immunology, particularly through his innovative patents. With a total of 4 patents, Wachtel's work focuses on the development of methods to stimulate immune responses using specific proteins.

Latest Patents

Wachtel's latest patents include groundbreaking inventions such as histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability. This invention describes the isolation and purification of histidine-tagged functional portions of intimin, a protein associated with the ability of certain pathogenic bacteria to adhere to epithelial cells. The invention further explores the use of intimin as an antigen to promote a protective immune response. Additionally, it discusses the combination of intimin with other antigens to enhance immune responses against various pathogens.

Career Highlights

Wachtel is affiliated with the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., where he continues to advance research in immunology. His work has been instrumental in developing methods that utilize transgenic plants to express intimin and stimulate protective immune responses against Enterohemorrhagic E. coli (EHEC) and other pathogens.

Collaborations

Wachtel has collaborated with notable colleagues, including Marian L McKee and Alison D O'Brien, who have contributed to his research endeavors.

Conclusion

Marian R Wachtel's innovative work in immunology has led to significant advancements in the field, particularly in the development of targeted immune responses. His contributions continue to impact the understanding and treatment of bacterial infections.