Margus Pooga

Title: Margus Pooga: Innovator in Membrane-Permeable Constructs

Introduction

Margus Pooga is a notable inventor based in Tartu, Estonia. He has made significant contributions to the field of biochemistry, particularly in the development of constructs that facilitate transport across lipid membranes. His innovative work has implications for intracellular delivery systems, which are crucial for various biomedical applications.

Latest Patents

Margus Pooga holds a patent for "Membrane-permeable constructs for transport across a lipid membrane." This patent describes constructs of peptides and nucleic acid analogs that are conjugated together to enable transport across lipid membranes. The constructs are designed to deliver materials into interactive contact with intracellular polynucleotides. The transport mechanism is effective through the exterior membrane of a cell and potentially through the walls of subcellular structures, including the nucleus and mitochondria. The patent highlights the use of peptide nucleic acid (PNA) analog sequences that are conjugated through a labile disulfide bond to transporting peptides, which are cleaved intracellularly to target mRNA or dsDNA.

Career Highlights

Margus Pooga has been associated with Perseptive Biosystems Inc., where he has furthered his research and development efforts. His work has been instrumental in advancing the understanding of membrane transport mechanisms and their applications in drug delivery and genetic engineering.

Collaborations

He has collaborated with notable scientists such as Ulo Langel and Tamas Bartfai, contributing to a rich exchange of ideas and innovations in the field of biochemistry.

Conclusion

Margus Pooga's contributions to the development of membrane-permeable constructs represent a significant advancement in the field of biochemistry. His innovative approaches have the potential to enhance intracellular delivery systems, paving the way for future biomedical applications.