Company Filing History:
Years Active: 2023
Title: Innovations by Marcos Malumbres
Introduction
Marcos Malumbres is a notable inventor based in Guadalix de la Sierra, Spain. He has made significant contributions to the field of regenerative medicine through his innovative research and patents. His work focuses on enhancing the potential of pluripotent cells, which are crucial for various medical applications.
Latest Patents
Marcos Malumbres holds a patent titled "Method for expanding stemness and differentiation potential of pluripotent cells." This invention is based on the discovery that increasing micro RNA-203 levels in induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) enhances their quality and ability to differentiate into multiple cell lineages. The method allows these cells to achieve further maturation properties without compromising their self-renewal capabilities. This effect is mediated through the miR-203-dependent control of de novo DNA methyltransferases Dnmt3a and Dnmt3b, which regulate the methylation landscape of pluripotent cells. The method can be implemented by overexpressing micro RNA-203 or by adding it to the cell culture medium, and it can be observed using various cellular and in vivo models. The resulting cells are naive pluripotent cells with an improved capacity to differentiate, making them suitable for regenerative medicine strategies.
Career Highlights
Throughout his career, Marcos Malumbres has worked with esteemed organizations, including the National Center for Oncological Research Carlos III (CNIO). His research has significantly advanced the understanding of pluripotent cells and their applications in medicine.
Collaborations
Marcos has collaborated with notable colleagues such as Maria Salazar-Roa and Marianna Trakala. Their joint efforts have contributed to the success of his research and innovations.
Conclusion
Marcos Malumbres is a pioneering inventor whose work in expanding the potential of pluripotent cells has opened new avenues in regenerative medicine. His contributions are vital for the future of medical science and therapy.