Location History:
- Santiago de Compostela, ES (2013)
- A Coruña, ES (2019)
Company Filing History:
2 out of 42 
1 out of 1 Years Active: 2013-2019
Title: Manuel Romero Bernárdez: A Pioneer in Quorum Sensing Inhibition
Introduction: Manuel Romero Bernárdez is a distinguished inventor based in A Coruña, Spain, recognized for his significant contributions to the field of molecular biology and microbiology. With two patents to his name, his work focuses on innovative solutions for quorum sensing, a critical process in microbial communication.
Latest Patents: His latest patents include groundbreaking inventions such as the "Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof." This invention delves into the cloning, sequencing, and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS) signals in the strain 20J (CECT7426). The patented gene encodes a unique peptide exhibiting lactonase activity with notably low identity percentages (less than 38%) compared to existing lactonases in other species. Furthermore, this peptide demonstrates a broad spectrum of activity against optionally substituted N-acyl-homoserine lactones (AHLs) and remains active across a pH range of 3 to 9. Its exceptional properties include resistance to proteinase K and chymotrypsin, as well as a non-interactive characteristic with β-lactam antibiotics. Additionally, he has developed methods for utilizing bacterial cells capable of degrading N-acyl homoserine lactones for quorum quenching, aimed at treating infectious bacterial illnesses and inhibiting biofilm formation.
Career Highlights: Manuel has had a notable career, notably associating with esteemed organizations such as the University of Santiago de Compostela and Fundación Pedro Barrié de la Maza. His work at these institutions has allowed him to advance his research and develop innovations that address critical challenges in microbiology.
Collaborations: Throughout his career, Manuel Romero Bernárdez has collaborated with talented coworkers including Ana Maria Otero Casal and Arturo Roca Rivada. These partnerships have further enriched his research endeavors, fostering an environment of innovation and discovery.
Conclusion: Manuel Romero Bernárdez stands out as a key figure in the realm of quorum sensing research, with significant patents that promise advancements in the treatment of bacterial infections and biofilm management. His dedication to innovation and collaboration positions him as a notable inventor in the scientific community.