Company Filing History:
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Years Active: 2017-2025
Title: Manabu Tokeshi: Innovator in Lipid Nanoparticle Technology
Introduction
Manabu Tokeshi is a prominent inventor based in Sapporo, Japan. He has made significant contributions to the field of lipid nanoparticle technology, particularly in applications related to genome editing and drug delivery systems. With a total of 3 patents to his name, Tokeshi's work is at the forefront of innovative solutions in biotechnology.
Latest Patents
Tokeshi's latest patents include a groundbreaking lipid nanoparticle designed for encapsulating nucleic acids required in genome editing. This invention addresses the challenge of achieving high genome editing efficiency through a novel alcohol dilution method using flow channels. The lipid nanoparticle comprises a lipid component, a DNA nuclease, a guide RNA, and a single-stranded oligonucleotide. The specific ratios of the lipid components are crucial for the nanoparticle's functionality, with the pH-sensitive cationic lipid making up 30-50 mol %, the neutral phospholipid 20-50 mol %, and the polyalkylene glycol-modified lipid 1-4 mol %.
Another significant patent involves a flow channel structure that enables the controlled production of lipid particles or micelles, which are essential for drug delivery systems. This innovative flow channel design features a two-dimensional structure with multiple baffles, allowing for precise control over particle size during the formation process.
Career Highlights
Throughout his career, Tokeshi has worked with esteemed institutions such as Hokkaido University and Tohoku University. His research has focused on advancing the understanding and application of lipid nanoparticles in various biomedical fields.
Collaborations
Tokeshi has collaborated with notable colleagues, including Masatoshi Maeki and Yusuke Sato. These partnerships have further enriched his research and contributed to the development of innovative technologies in lipid nanoparticle applications.
Conclusion
Manabu Tokeshi's contributions to lipid nanoparticle technology exemplify the impact of innovative research in biotechnology. His patents reflect a commitment to enhancing genome editing and drug delivery systems, paving the way for future advancements in the field.