Maider Zabala Ugalde

Title: Maider Zabala Ugalde: Innovator in Cancer Research

Introduction

Maider Zabala Ugalde is a prominent inventor based in Stanford, California. She has made significant contributions to the field of cancer research, particularly in understanding the mechanisms of differentiation in cancer cells. Her innovative work has led to the development of a patent that addresses critical pathways involved in tumorigenesis.

Latest Patents

Maider Zabala Ugalde holds a patent titled "Compositions and methods for modulating left-right differentiation factor (LEFTY) and bone morphogenic factor (BMP)." This patent reveals that LEFTY inhibits differentiation-promoting pathways such as BMP7/pSMAD5 in breast cancer cell lines. The findings indicate that LEFTY competes with BMP7 to bind to its cell surface receptor BMPR2, leading to the inhibition of pSMAD5. The LEFTY-BMPR2 interaction is dominant over BMP-BMPR2 in tumorigenic cells, resulting in diminished pSMAD status. In contrast, non-tumorigenic cells exhibit minimal LEFTY-BMPR2 interaction, increased BMP7-BMPR2 association, and elevated pSMAD. The compositions and methods described in the patent can be utilized in the diagnosis and therapy of cancer and other conditions, as well as to promote the proliferation of stem cells.

Career Highlights

Throughout her career, Maider has worked with notable organizations, including Cz Biohub SF, LLC and Leland Stanford Junior University. Her research has been instrumental in advancing the understanding of cancer biology and therapeutic approaches.

Collaborations

Maider has collaborated with esteemed colleagues such as Michael F. Clarke and Neethan A. Lobo. These partnerships have further enriched her research and contributed to the scientific community's knowledge in the field.

Conclusion

Maider Zabala Ugalde is a trailblazer in cancer research, with a focus on the modulation of critical differentiation factors. Her innovative patent and collaborative efforts highlight her commitment to advancing medical science and improving therapeutic strategies for cancer treatment.