Lukas Jeker

Title: Innovations of Lukas Jeker in Allele Editing

Introduction

Lukas Jeker is a notable inventor based in Riehen, Switzerland. He has made significant contributions to the field of genetic engineering, particularly in allele editing. With a total of 2 patents, his work focuses on advancing methods for gene editing and repair within eukaryotic cells.

Latest Patents

One of Lukas Jeker's latest patents is titled "Allele editing and applications thereof." This invention relates to a method for determining a homology directed repair (HDR) event within a eukaryotic cell. The method involves a cell that expresses a first isoform of a surface protein, which differs from a second isoform regarding an amino acid marker. The process includes inducing a DNA double strand break, providing a HDR template DNA construct with the corresponding amino acid marker, and determining the expression of either isoform of the surface protein. Successful expression of the second isoform indicates a successful HDR event. Additionally, the invention encompasses methods for editing a genomic location of interest and selectively depleting or enriching edited cells within a mixture of non-edited and edited cells.

Career Highlights

Lukas Jeker has worked at prestigious institutions, including the University of Basel. His research and innovations have contributed to the advancement of genetic engineering techniques, particularly in the context of allele editing.

Collaborations

Lukas has collaborated with notable colleagues such as Mara Kornete and Lorenza Bordoli Schwede. Their combined expertise has furthered the development of innovative methods in the field.

Conclusion

Lukas Jeker's contributions to allele editing represent a significant advancement in genetic engineering. His innovative methods and collaborations continue to influence the field and pave the way for future research and applications.