Lourival Domingos Possani-Postay

Title: Innovations of Lourival Domingos Possani-Postay

Introduction

Lourival Domingos Possani-Postay is a prominent inventor known for his significant contributions to the field of immunology through his innovative research on scorpion peptides. He is based in Morelos, Mexico, and has been instrumental in developing novel therapeutic agents that target specific potassium channels implicated in various immunological diseases.

Latest Patents

Possani-Postay holds two notable patents, Vm23 and Vm24. These peptides are designed to block human T-lymphocyte potassium channels, specifically the Kv1.3 subtype, with high selectivity. The peptides have shown promise in decreasing in vivo delayed-type hypersensitivity (DTH) responses in rats. The Kv1.3 channels are known to play a crucial role in immunological diseases and graft rejections. His patents disclose peptides capable of blocking these channels with high affinity and specificity, along with their pharmaceutical compositions and methods for use in treating various immunological conditions. The exemplary peptides, Vm23 and Vm24, are isolated from the venom of the Mexican scorpion and have demonstrated an almost irreversible binding to hKv1.3 channels, with a Kd value in the picomolar range. Vm24 has been chemically synthesized and successfully used in in vivo experiments to treat sensitized rats without toxicity to mice at high concentrations.

Career Highlights

Possani-Postay is affiliated with the Universidad Nacional Autonoma De Mexico, where he continues to advance research in the field of immunology and peptide synthesis. His work has garnered attention for its potential applications in treating various immunological conditions and for diagnostic purposes.

Collaborations

He has collaborated with notable colleagues, including Barbara Selisko and Consuelo Garcia-Rodriguez, contributing to the advancement of research in his field.

Conclusion

Lourival Domingos Possani-Postay's innovative work on scorpion peptides represents a significant advancement in immunological research, with the potential to lead to new therapeutic options for patients suffering from related diseases. His contributions continue to inspire further research and development in this critical area of medicine.