Louise Pilote

Title: The Innovations of Louise Pilote

Introduction

Louise Pilote is a notable inventor based in Laval, Canada. She has made significant contributions to the field of biochemistry, particularly in the development of methods for producing active forms of proteases. Her work has implications for therapeutic agents against Hepatitis C virus (HCV).

Latest Patents

Louise Pilote holds 2 patents. Her latest patents focus on the "Purified active HCV NS2/3 protease." This invention outlines a method for producing a refolded, inactive form of recombinantly produced NS2/3 protease. The process involves purifying the protease from inclusion bodies using a chaotropic agent and refolding it with a reducing agent and lauryldiethylamine oxide (LDAO). The invention also includes a method for activating the refolded inactive NS2/3 protease by adding an activation detergent. This innovative approach allows for the production of large amounts of active NS2/3 protease, facilitating the screening of small molecules and ligands as potential inhibitors, which may serve as therapeutic agents against HCV.

Career Highlights

Louise Pilote is currently employed at Boehringer Ingelheim (Canada) Ltd. Her work at this esteemed company has allowed her to further her research and development in the field of protease production and its applications in medicine.

Collaborations

Throughout her career, Louise has collaborated with notable colleagues, including Daniel Lamarre and Diane Thibeault. These partnerships have contributed to her innovative research and the advancement of her projects.

Conclusion

Louise Pilote's contributions to the field of biochemistry and her innovative patents highlight her role as a leading inventor in the development of therapeutic agents against HCV. Her work continues to impact the scientific community and offers promising avenues for future research.