Lit Hsin Loo

Title: Innovations in Liver Injury Prediction by Lit Hsin Loo

Introduction

Lit Hsin Loo is an accomplished inventor based in Singapore, known for his significant contributions to the field of biomedical research. He has developed innovative methods that enhance the prediction of liver injury caused by various compounds. His work is particularly relevant in the context of drug development and safety assessment.

Latest Patents

One of Lit Hsin Loo's notable patents is titled "High throughput method for accurate prediction of compound-induced liver injury." This patent describes a method and system for predicting liver injury in vivo due to hepatocyte damage by a test compound. The method involves acquiring images of fluorescently stained cells from a cell culture treated with a range of doses of the test compound and its vehicle. The cells may include primary or immortalized hepatocytes, hepatoma cells, or induced pluripotent stem cell-derived hepatocyte-like cells. The acquired images are then segmented, and various phenotypic features are extracted and analyzed. These features include intensity, textural, morphological, and ratiometric characteristics, which are crucial for assessing liver injury. The method ultimately predicts the probability of liver injury based on normalized changes in the extracted features using machine learning techniques.

Career Highlights

Lit Hsin Loo is affiliated with the Agency for Science, Technology and Research, where he continues to advance his research in liver injury prediction. His innovative approach has garnered attention in the scientific community, contributing to safer drug development practices.

Collaborations

Lit Hsin Loo has collaborated with notable colleagues, including Daniele Zink and Nur Faezah Begum Akbar Hussain. These collaborations have further enriched his research and expanded the impact of his work in the field.

Conclusion

Lit Hsin Loo's contributions to the prediction of compound-induced liver injury represent a significant advancement in biomedical research. His innovative methods and collaborative efforts continue to shape the future of drug safety assessment.