Lin Hong

Title: Innovations of Lin Hong in Memapsin Research

Introduction

Lin Hong is an accomplished inventor based in Oklahoma City, OK (US). He has made significant contributions to the field of biochemistry, particularly in the development of inhibitors for memapsin 2, which is relevant for Alzheimer's disease treatment.

Latest Patents

Lin Hong holds 2 patents related to catalytically active recombinant memapsin 2. His latest patents detail methods for producing purified, catalytically active recombinant memapsin 2. The research includes determining the substrate and subsite specificity of the enzyme, which has led to the design of substrate analogs that can inhibit the function of memapsin 2. These analogs are based on peptide sequences related to natural substrates and contain amide bond analogs that cannot be cleaved by memapsin 2. The synthesis of two substrate analogues, OMR99-1 and OM99-2, was developed, with OM99-2 demonstrating an inhibition constant of 1.6×10 M against recombinant pro-memapsin 2. Crystallography studies have provided insights into the three-dimensional structure of the protein, aiding in the design of new inhibitors for diagnostic and therapeutic applications.

Career Highlights

Lin Hong has worked with notable institutions such as the Oklahoma Medical Research Foundation and the University of Illinois. His work has been pivotal in advancing the understanding of memapsin 2 and its implications in Alzheimer's disease.

Collaborations

Some of his notable coworkers include Jordan J N Tang and Xinli Lin. Their collaborative efforts have contributed to the innovative research surrounding memapsin 2.

Conclusion

Lin Hong's innovative work in the field of biochemistry, particularly regarding memapsin 2, showcases his dedication to advancing medical science. His patents and research have the potential to significantly impact the treatment and prevention of Alzheimer's disease.