Company Filing History:
Years Active: 1997-2004
Title: Lihsyng Stanford Lee: Innovator in Biochemical Modifications
Introduction
Lihsyng Stanford Lee is a notable inventor based in Princeton Junction, NJ (US). He has made significant contributions to the field of biochemistry, particularly in the development of modified polypeptides and protein compositions. With a total of 3 patents, his work has implications for therapeutic applications and protein stability.
Latest Patents
One of his latest patents is focused on polyalkylene oxide-modified single chain polypeptides. This invention involves the chemical modification of single chain polypeptides through the covalent attachment of strands of poly(ethylene glycol) (PEG) and similar poly(alkylene oxides). These modifications enhance the binding ability and specificity of the polypeptides, making them useful in various therapeutic applications due to their reduced immunogenicity and longer half-life in the bloodstream. Another significant patent relates to stabilized monomeric protein compositions. This invention comprises a monomeric protein and a storage-stabilizing amount of sucrose, histidine, or glycine, which prevents aggregation during freeze/thaw cycles. These compositions are particularly beneficial for pharmaceutically-acceptable, single-chain antigen-binding proteins.
Career Highlights
Lihsyng Stanford Lee has been associated with Enzon, Inc., where he has contributed to innovative research and development in biochemistry. His work has been instrumental in advancing the understanding and application of modified proteins in therapeutic settings.
Collaborations
Some of his notable coworkers include Marc D. Whitlow and Robert G. L. Shorr. Their collaborative efforts have further enhanced the research and development initiatives at Enzon, Inc.
Conclusion
Lihsyng Stanford Lee's contributions to the field of biochemistry through his patents and work at Enzon, Inc. highlight his role as an innovator in the development of therapeutic proteins. His inventions continue to influence the landscape of biochemical research and applications.