Company Filing History:
Years Active: 2000-2003
Title: Innovations of Liane Chen in Adenoviral Vector Systems
Introduction
Liane Chen is a notable inventor based in Hamilton, Canada, recognized for her contributions to the field of biotechnology. With a focus on adenoviral vector systems, she has made significant advancements that enhance the production of high-capacity cloning vectors. Her work has implications for gene therapy and vaccine development.
Latest Patents
Liane Chen holds two patents, both centered around the development of improved helper-dependent vector systems for adenoviral cloning. The first patent details a system that utilizes DNA size packaging constraints imposed on a pIX-defective adenoviral virion. This system prevents the packaging of DNA larger than approximately 35 kb, allowing for the creation of helper viruses that do not package their DNA. The invention also integrates the Cre-loxP helper-dependent system to reduce the presence of contaminating helper viruses in vector preparations. Additionally, this methodology is applied for vector growth, showcasing its versatility and potential for enhancing adenoviral vector production.
Career Highlights
Liane Chen is currently employed at Merck & Company, Inc., where she continues to innovate in the field of biotechnology. Her work is pivotal in advancing the capabilities of adenoviral vectors, which are crucial for various therapeutic applications.
Collaborations
Throughout her career, Liane has collaborated with esteemed colleagues, including Frank L Graham and Robin Parks. These partnerships have fostered a collaborative environment that enhances research and development efforts in her field.
Conclusion
Liane Chen's contributions to adenoviral vector systems represent a significant advancement in biotechnology. Her innovative patents and collaborative efforts continue to influence the landscape of gene therapy and vaccine development.