Company Filing History:
1 out of 3 
1 out of 1 Years Active: 2002-2006
Title: The Innovations of Liana Juliana Josephine Margriet Steeghs
Introduction
Liana Juliana Josephine Margriet Steeghs is an innovative inventor based in Utrecht, Netherlands. She has contributed significantly to the field of vaccine development, holding two patents that focus on the modification and utilization of gram-negative mucosal bacteria.
Latest Patents
Her latest patents reflect her groundbreaking work in immunology. The first patent discusses "Mutants of gram negative mucosal bacteria and application thereof in vaccines." This invention outlines a method to inactivate the early stage of lipid A synthesis in mucosal gram-negative bacteria while maintaining cell viability. Notably, by mutating the lpxA gene, Liana developed lpxA knockout mutants that are completely lipopolysaccharide (LPS)-deficient. This discovery is crucial for understanding outer membrane structure and biogenesis, presenting new avenues for vaccine development by allowing for the easy isolation of endotoxin-free purified proteins or outer membranes for immunization purposes.
Her second patent, "LPS with reduced toxicity from genetically modified gram negative bacteria," introduces new compounds that can act as adjuvants in vaccines. This involves recombinant LPS with a reduced number of secondary acyl chains, enhancing the safety and efficacy of the molecules. Such innovations lay the groundwork for safer vaccines, revolutionizing immunological research.
Career Highlights
Throughout her career, Liana has worked with prominent entities such as the Ministry of Health, Welfare and Sport in the Netherlands. Her contributions to research and development in the medical field have established her as a valuable asset in vaccine innovation.
Collaborations
Liana has collaborated with notable researchers in her field, including Peter Andre Van Der Ley and Hendrik Jan Hamstra. These partnerships have allowed for the exchange of ideas and cooperative efforts leading to significant advancements in her areas of expertise.
Conclusion
Liana Juliana Josephine Margriet Steeghs exemplifies the spirit of innovation in the science community. With her patents paving the way for enhanced vaccine development, her work holds tremendous promise for future medical applications. As she continues to push the boundaries of research, her contributions will undoubtedly impact the field of immunology in profound ways.