Leonard Chia

Title: Innovations by Leonard Chia in Nanostructured Materials

Introduction

Leonard Chia is a notable inventor based in Singapore, recognized for his contributions to the field of nanostructured materials. He has been instrumental in developing innovative solutions that enhance the effectiveness of medical applications, particularly in antibiotic delivery systems. With a total of 2 patents, his work demonstrates a commitment to advancing technology in healthcare.

Latest Patents

One of Leonard Chia's latest patents is focused on a nanostructured material formulated with bone cement for effective antibiotic delivery. This invention utilizes mesoporous silica nanoparticles and other nanostructured materials to create a polyacrylate-based bone cement. The formulation allows for an enhanced and controlled release of active ingredients, such as antibiotics, overcoming the limitations of low antibiotic release from commercial polyacrylate-based bone cements. Notably, this innovative bone cement enables a sustained release of antibiotics over a period of 80 days, achieving 70% of total drug release, compared to only 5% from commercial alternatives on the first day. Additionally, the mechanical properties of the formulated bone cement are well retained, exhibiting good antibacterial properties and low cytotoxicity to mouse fibroblast cells.

Another significant patent by Chia involves mesoporous material excipients for poorly aqueous soluble ingredients. This invention encompasses formulations and methods for producing solid dispersions that include mesoporous materials with poorly soluble active ingredients. The active ingredient is maintained in an amorphous state and is entrapped in the nanosized pores of the mesoporous excipients through a co-spray drying process. The pore walls of the mesoporous channels stabilize the amorphous form against re-crystallization, resulting in enhanced dissolution rates and stability during extended storage under stress test conditions.

Career Highlights

Leonard Chia is affiliated with the Agency for Science, Technology and Research, where he continues to contribute to innovative research and development. His work has significantly impacted the field of biomedical engineering, particularly in improving drug delivery systems.

Collaborations

Chia has collaborated with notable colleagues, including Shou-Cang Shen and Wai Kiong Ng, to further advance his research and innovations in the field.

Conclusion

Leonard Chia's innovative work in nanostructured materials and drug delivery systems showcases his dedication to improving healthcare solutions. His patents