Leonard Bright

Title: Innovations by Leonard Bright in Stabilized Lipid Assemblies

Introduction

Leonard Bright is an accomplished inventor based in Tucson, AZ. He has made significant contributions to the field of lipid assemblies, particularly through his innovative patent that addresses the preparation of stabilized lipid assemblies. His work is crucial for advancing the functionality of reconstituted membrane proteins.

Latest Patents

Leonard Bright holds a patent titled "Systems and methods of preparing stabilized lipid assemblies." This patent describes a process involving the direct polymerization of lipid monomers or polymer scaffolding of non-lipid monomers. The method utilizes irradiation or redox polymerization performed at neutral pH, resulting in stabilized lipid assemblies. An initiator-buffer component and a NaHSO3 redox mixture are employed to polymerize reactive lipid monomers under near-neutral pH conditions, preserving the functionality of reconstituted membrane proteins. The patent also highlights the improved stability of black lipid membranes (BLMs) achieved through chemical cross-linking of polymerizable, hydrophobic, and commercially available non-lipid monomers. These monomers are partitioned into the suspended lipid membranes, and the BLMs are suspended across low surface energy apertures. The substrate apertures, modified with low surface energy and amphiphobic properties, facilitate the reproducible formation of BLMs by promoting interactions between the lipid tail and the substrate material. Additionally, polymeric lipid bilayer membranes are prepared by photochemical or redox-initiated polymerization of polymerizable lipid monomers, which are then disposed onto supporting substrates for use in chromatography columns.

Career Highlights

Leonard Bright is affiliated with the University of Arizona, where he continues to contribute to research and innovation in his field. His work has garnered attention for its potential applications in various scientific and industrial domains.

Collaborations

Leonard has collaborated with notable colleagues, including Steven Scott Saavedra and Craig A Aspinwall. Their combined expertise has furthered advancements in the study of lipid assemblies and related technologies.

Conclusion

Leonard Bright's innovative work in the preparation of stabilized lipid assemblies represents a significant advancement in the field of biochemistry and materials science. His contributions are poised to impact various applications, particularly in the realm of membrane protein functionality.