Lee-Peng Lee

Title: Innovations of Lee-Peng Lee in Ligand Design

Introduction

Lee-Peng Lee is an accomplished inventor based in Cambridge, MA (US). He has made significant contributions to the field of ligand design, particularly in the context of drug development. His innovative methodologies have the potential to enhance the effectiveness of therapeutic agents.

Latest Patents

Lee holds a patent for a "Computer system and process for identifying a charge distribution which minimizes electrostatic contribution to binding at binding between a ligand and a molecule in a solvent and uses thereof." This computer-implemented process involves a methodology for determining properties of ligands, which can be utilized for designing ligands that bind with protein or other molecular targets, such as HIV. The methodology defines the electrostatic complement for a given target site and geometry, allowing for the discovery of ligands through explicit construction and the design of combinatorial libraries. The definition of an electrostatic complement has proven useful in ligand design by optimizing the tradeoff between unfavorable desolvation energy and favorable interactions in the complex.

Career Highlights

Lee-Peng Lee is affiliated with the Massachusetts Institute of Technology, where he continues to advance research in ligand design and drug development. His work has garnered attention for its innovative approach to solving complex problems in molecular binding.

Collaborations

Lee has collaborated with notable colleagues, including Bruce Tidor and Sara E Dempster, contributing to the advancement of research in his field.

Conclusion

Lee-Peng Lee's innovative methodologies in ligand design represent a significant advancement in the field of drug development. His contributions have the potential to lead to more effective therapeutic agents in the future.