Leah Gotlib

Title: Leah Gotlib - Innovator in HIV Research

Introduction

Leah Gotlib is a prominent inventor based in Wynnewood, PA (US). She has made significant contributions to the field of HIV research, particularly in the development of assays that help identify drug-resistant strains of the virus. Her work is crucial in the ongoing battle against HIV/AIDS.

Latest Patents

Leah Gotlib holds a patent for a "Color screening assay for identifying inhibitor resistant HIV protease." This innovative chromogenic assay is designed for the identification and isolation of drug-resistant HIV protease mutants. Additionally, the assay is useful for screening new inhibitors of HIV protease that are not affected by the drug resistance of the HIV protease. The assay features a vector with a regulatable promoter that controls the transcription of two adjacent structural sequences. One sequence codes for HIV protease or its mutant, while the other codes for beta-galactosidase with an amino acid substrate insert that is cleavable by HIV protease. Furthermore, a library of HIV proteases is described, isolated in the form of a collection of such vectors, known as a color screen vector library. Leah Gotlib's patent portfolio includes 1 patent.

Career Highlights

Leah Gotlib is currently employed at Merck & Co., Inc., where she continues her research and development efforts in the field of HIV. Her work has been instrumental in advancing the understanding of HIV protease and its inhibitors.

Collaborations

Throughout her career, Leah has collaborated with notable colleagues, including Jon H. Condra and Donald J. Graham. These collaborations have further enhanced her research and contributed to the development of innovative solutions in HIV treatment.

Conclusion

Leah Gotlib is a dedicated inventor whose work in HIV research has the potential to make a significant impact on public health. Her innovative approaches to identifying drug-resistant HIV protease mutants are paving the way for new treatment options.