Lawrence John Penkler

Title: Lawrence John Penkler: Innovator in Amphiphilic Macrocyclic Derivatives

Introduction

Lawrence John Penkler is a notable inventor based in Port Elizabeth, South Africa. He has made significant contributions to the field of chemistry, particularly in the development of amphiphilic macrocyclic derivatives. With a total of 7 patents to his name, Penkler's work has implications in various applications, including pharmaceuticals.

Latest Patents

Among his latest patents, Penkler has developed "Amphiphilic macrocyclic derivatives and their analogues." This invention focuses on soluble amphiphilic macrocycle analogues that possess lipophilic groups on one side and hydrophilic groups on the other. These derivatives can self-assemble in aqueous solvents, forming micelles or vesicles, which can be utilized for the solubilization and stabilization of various compounds. Another significant patent is for "Alprazolam inclusion complexes and pharmaceutical compositions thereof." This invention details a pharmaceutical composition that includes an inclusion complex of alprazolam and a water-soluble 2-hydroxypropyl-beta-cyclodextrin, designed for transmucosal delivery.

Career Highlights

Throughout his career, Penkler has worked with various companies, including Farmarc Nederland Bv and Pharmatec International S.r.l. His innovative work has positioned him as a key figure in the development of new pharmaceutical formulations and delivery systems.

Collaborations

Some of his notable coworkers include Lueta Ann Glintenkamp and Michiel Coenraad Van Oudtshoorn. Their collaborative efforts have contributed to the advancement of research in the field of macrocyclic chemistry.

Conclusion

Lawrence John Penkler's contributions to the field of chemistry, particularly through his patents on amphiphilic macrocyclic derivatives, highlight his innovative spirit and dedication to advancing pharmaceutical science. His work continues to influence the development of new therapeutic solutions.