Company Filing History:
Years Active: 2002-2009
Title: The Innovative Contributions of Inventor Laurie A Graham
Introduction
Laurie A Graham, based in Kingston, Canada, is a distinguished inventor known for his groundbreaking work in the field of thermal hysteresis proteins. With a total of three patents to his name, Graham’s research has significant implications in various applications, particularly in the biotechnology sector.
Latest Patents
Graham’s most recent patents focus on a novel class of thermal hysteresis (antifreeze) proteins (THP) extracted and purified from the mealworm beetle. These proteins exhibit up to 100 times the specific activity of traditional fish antifreeze proteins. Internal sequencing and subsequent cDNA cloning have allowed for the production of these proteins in bacteria, confirming their identity and functional capabilities. The THPs range from 8.4 to 10.7 kDa and are characterized by their unique composition, largely consisting of 12-amino-acid repeats. Notably, at a concentration of 55 μg/mL, these THPs can lower the freezing point by 1.6°C below the melting point. Furthermore, at about 1 mg/mL concentration, these proteins contribute to a thermal hysteresis of 5.5°C observed in Tenebrio larvae, functioning through an adsorption-inhibition mechanism that results in the formation of oval-shaped ice crystals with curved prism faces.
Career Highlights
Laurie A Graham is affiliated with Queen's University at Kingston, where he continues to advance his research in the field of antifreeze proteins. His work is pivotal in enhancing our understanding of how these proteins can be harnessed for various industrial and medical applications.
Collaborations
Throughout his career, Graham has collaborated with notable colleagues such as Yih-Cherng Liou and Virginia K Walker, contributing to a rich exchange of ideas and advancements in their shared field of study.
Conclusion
Laurie A Graham's innovative research and patents not only highlight his contributions to the scientific community but also exemplify the potential for novel biotechnological applications derived from natural organisms. His work serves as an inspiration for future inventors aiming to harness biological mechanisms for technological advancement.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.