Company Filing History:
10 out of 28 
10 out of 1,189 
10 out of 69 
Years Active: 2015-2025
Title: Innovations in HIV Research by Laura Marjorie Walker
Introduction
Laura Marjorie Walker is a prominent inventor based in San Diego, CA. She has made significant contributions to the field of HIV research, holding a total of 10 patents. Her work focuses on developing monoclonal antibodies that target the HIV-1 envelope glycoprotein, which is crucial for neutralizing the virus.
Latest Patents
One of her latest patents involves monoclonal antibodies directed against trimeric forms of the HIV-1 envelope glycoprotein with broad and potent neutralizing activity. This invention outlines a method for obtaining broadly neutralizing antibodies (bNabs) by screening memory B cell cultures from donor PBMC samples for neutralization activity against various HIV-1 species. The process includes cloning memory B cells that exhibit broad neutralization activity and rescuing monoclonal antibodies from these cultures. The resultant antibodies are characterized by their ability to selectively bind to epitopes from the Env proteins in both native and monomeric forms, as well as their effectiveness in inhibiting infections from multiple HIV-1 clades. Additionally, the patent provides methods for generating these antibodies through immunization using epitopes from conserved regions within the variable loops of gp120, along with immunogens for generating anti-HIV1 bNAbs and methods for vaccination using suitable epitopes.
Career Highlights
Laura has worked with notable organizations such as Theraclone Sciences, Inc. and The Scripps Research Institute. Her innovative research has positioned her as a key figure in the fight against HIV, contributing to advancements in prophylaxis, diagnosis, and treatment of HIV infections.
Collaborations
Throughout her career, Laura has collaborated with esteemed colleagues, including Po-Ying Chan-Hui and Steven Frey. These partnerships have further enhanced her research and development efforts in the field of HIV.
Conclusion
Laura Marjorie Walker's contributions to HIV research through her innovative patents and collaborations highlight her dedication to advancing medical science. Her work continues to pave the way for new treatments and preventive measures against HIV infection.