This inventor holds 2 USPTO granted patents. Top assignee: American Home Products Corporation. Active years: 1978-1980.
Company Filing History:
Years Active: 1978-1980
Title: Innovations of Larry Stein in Pharmaceutical Science
Introduction
Larry Stein is a notable inventor based in Haverford, PA (US). He has made significant contributions to the field of pharmaceutical science, particularly in the development of novel compounds with therapeutic applications. With a total of 2 patents, his work has the potential to impact pain management and narcotic antagonism.
Latest Patents
One of Larry Stein's latest patents focuses on dipeptide narcotic antagonists. This patent discloses novel dipeptides of the formula: A--X--Y--B, wherein X is D-Tyr or L-Tyr; Y is D-Ala, L-Ala, D-Ser, L-Ser, or Gly; with the proviso that at least one of X and Y is of the D-configuration. A is hydrogen, allyl, or lower alkyl of 1 to 3 carbon atoms, and B is --NH.sub.2, --OMe, or --NHNH.sub.2. The patent also covers pharmacologically acceptable salts and pharmaceutical compositions containing these compounds, along with a process for antagonizing the effects of a narcotic analgesic agent in warm-blooded animals. Another significant patent involves polypeptides with morphine-like activity. The polypeptide H-Tyr-Gly-Gly-Phe-Leu-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH, or a non-toxic salt thereof, has been shown to exert an analgesic effect in rats when injected into the lateral brain ventricle.
Career Highlights
Larry Stein is associated with American Home Products Corporation, where he has been able to leverage his expertise in pharmaceutical innovations. His work has contributed to advancements in pain management therapies, showcasing his commitment to improving patient outcomes through scientific research.
Collaborations
Throughout his career, Larry has collaborated with notable colleagues such as James D Beluzzi and William H McGregor. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas in the pharmaceutical field.
Conclusion
Larry Stein's contributions to pharmaceutical science through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in pain management and narcotic antagonism.